Fig. 2: Overview the dual roles of NPR receptors across malignancies.
From: The role and clinical value of natriuretic peptide receptor family in malignant tumor
NPRA is an oncogene. NPRA promotes proliferation, invasion, and angiogenesis in breast, gastric, and squamous cell carcinomas through activation of STAT3-MMP9, HIF-1α-VEGF pathways, and that its pro-carcinogenic effects are conserved across a wide range of tumors. NPRB changes in the level of its ligand, CNP, correlate with prostate cancer progression. NPRC exhibits dual functions: it promotes tumor progression by scavenging natriuretic peptides in prostate and colorectal cancers, whereas it exerts an oncogenic role through the suppression of the PI3K/AKT signaling pathway in osteosarcoma.
