Fig. 3: Tissue-specific impacts of NAMPT dysregulation on age-related disorders. | Cell Death Discovery

Fig. 3: Tissue-specific impacts of NAMPT dysregulation on age-related disorders.

From: Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications

Fig. 3

Declining NAMPT levels are critically linked to the progression of age-related diseases across multiple tissues, including skeletal muscle, adipose tissue, and the nervous system. In skeletal muscle, reduced NAMPT activity contributes to osteoarthritis, osteoporosis, and age-related bone loss. Within adipose tissues, NAMPT is essential for beige adipogenesis, and its deficiency drives metabolic derangements such as insulin resistance, hyperinsulinemia, and hypoadiponectinemia. In the nervous system, NAMPT depletion induces motor dysfunction, neurodegeneration, and Parkinson’s disease-like phenotypes in murine models, ultimately leading to premature mortality. Restoring NAMPT levels in these tissues ameliorates corresponding aging-associated pathologies. Furthermore, NAMPT exhibits inhibitory effects on the senescence-associated secretory phenotype (SASP), underscoring its dual role in modulating both tissue-specific dysfunction and systemic inflammatory cascades during aging.

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