Fig. 4: NAMPT and NAD+ metabolism in tumor growth and immunity. | Cell Death Discovery

Fig. 4: NAMPT and NAD+ metabolism in tumor growth and immunity.

From: Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications

Fig. 4

In tumor growth, NAMPT-mediated NAD⁺ synthesis contributes to cellular energetics, enabling sustained proliferation, resistance to cell death, and activation of invasion and metastasis. In the context of tumor immunity, NAMPT influences the immune microenvironment by promoting an immunosuppressive tumor milieu, characterized by the activation of tumor-associated macrophages (TAMs), inactivation of natural killer (NK) cells, and the presence of immature neutrophils. These immune alterations enable the tumor to evade immune destruction, including the suppression of CD8⁺ T cell-mediated cytotoxicity.

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