Fig. 8: Compound 89 showed antitumor activity in human tumor organoids. | Cell Death Discovery

Fig. 8: Compound 89 showed antitumor activity in human tumor organoids.

From: Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy

Fig. 8

A Patients’ basic information of the established PDOs and the responses to 89. B The established PDOs were treated with increasing concentrations of 89 for 24 h, and representative images of the morphology of the PDOs were shown (scale bar, 20 μm). C The line graphs showed the cell viability of the PDOs treated with different concentrations of 89. D Bright-field microscopy images showed the changes in the size and status of the PDOs after treatment with different concentrations of 89 (scale bar, 10 μm). E Relative PDOs density in response to different concentrations of 89. *p < 0.05, **p < 0.01, ***p < 0.001.

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