Table 2 Significantly enriched miRNA categories related to oxidative stress and dopamine metabolism in EVs isolated from high-grade glioma patient plasma.
Category | Subcategory | Enrichment | False discovery rate | Observed mRNA |
|---|---|---|---|---|
Stress | ||||
Pathways (miRWalk) | WP408 Oxidative stress | Over-represented | 0.0025 | 10 |
Pathways (miRWalk) | hsa00620 Pyruvate metabolism | Over-represented | 0.004 | 10 |
Pathways (miRWalk) | hsa00480 Glutathione metabolism | Over-represented | 0.0043 | 8 |
Pathways (miRWalk) | P00046 Oxidative stress response | Over-represented | 0.0065 | 11 |
Pathways (miRWalk) | hsa00270 Cysteine and methionine metabolism | Over-represented | 0.0072 | 9 |
Pathways (miRWalk) | WP3 Keap1 Nrf2 | Over-represented | 0.0094 | 6 |
Pathways (miRWalk) | WP15 Selenium | Over-represented | 0.0126 | 11 |
Pathways (miRWalk) | WP28 Selenium metabolism and selenoproteins | Over-represented | 0.0146 | 7 |
Pathways (miRWalk) | WP314 FAS pathway and stress induction of HSP regulation | Over-represented | 0.0149 | 11 |
Dopamine metabolism | ||||
Pathways (miRWalk) | hsa00360 Phenylalanine metabolism | Over-represented | 0.0013 | 7 |
Pathways (miRWalk) | hsa00350 Tyrosine metabolism | Over-represented | 0.0025 | 7 |
Pathways (miRWalk) | hsa00340 Histidine metabolism | Over-represented | 0.0051 | 6 |
Pathways (miRWalk) | P02787 Vitamin B6 metabolism | Over-represented | 0.0093 | 4 |
Pathways (miRWalk) | hsa00750 Vitamin B6 metabolism | Over-represented | 0.0146 | 4 |
Pathways (miRWalk) | hsa00400 Phenylalanine tyrosine and tryptophan biosynthesis | Over-represented | 0.0149 | 3 |
Pathways (miRWalk) | P02759 Pyridoxal 5 phosphate biosynthesis | Over-represented | 0.0149 | 3 |
Pathways (miRWalk) | hsa00380 Tryptophan metabolism | Over-represented | 0.0234 | 6 |
Pathways (miRWalk) | P00044 Nicotinic acetylcholine receptor signaling pathway | Over-represented | 0.0437 | 8 |
