Table 1 Writers, readers, and erasers of lactylation.

From: Roles of lactylation in lipid metabolism and related diseases

Writers

Erasers

Readers

1) KATs

1) Zn2+ dependent:

BRG1

P300/CBP family (P300, CBP)

Class I (HDAC1–3 and 8)

DPF2

GNAT family (GCN5/KAT2A, YiaC)

Class II (II b: HDAC 6)

TRIM33

MYST family (MOF/KAT8, TIP60/KAT5, HBO1/KAT7)

2) NAD+ dependent:

 

2) AARSs family (AARS1, AARS2)

Class III (SIRT1–3, 6, and CobB)

 

3) Others (ATAT1, ACAT2, ESCO2, NAA10, HDAC6)

  
  1. KATs Lysine acyltransferases, CBPCREB-binding protein, GNAT GCN5-related N-acetyltransferase, MYST Moz-Ybf2/Sas3-Sas2-Tip60, TIP60 Tat-interactive protein 60, KAT (lysine acetyltransferase), MOF (males absent on the first), HBO1 (histone acetyltransferase binding to ORC1), ATAT1 (α-tubulin acetyltransferase 1), ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2), NAA10 N-α-acetyltransferase 10, AARS alanyl-tRNA synthetase, HDAChistone deacetylase, SIRTs (Sirtuins), TRIM33 (tripartite motif containing 33), DPF2 (double PHD finger 2), BRG1 (Brahma-related gene 1).
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