Table 3 Lactylation events that act in combination with other PTMs to regulate lipid metabolism.
From: Roles of lactylation in lipid metabolism and related diseases
Lactylation | Other PTMs | Functions | Diseases | Refs |
|---|---|---|---|---|
PCK2 K100 | Ubiquitination | Prevent Parkin-mediated polyubiquitination of OXSM | LT | [44] |
H3K18la | m6A modification and acetylation | Promote m6A-modified NEAT1 stability, activate SCD by histone acetylation | HCC | [45] |
H3K18la | m6A modification | Promote METTL3-mediated SCD1 m6A levels | NAFLD | [48] |
H3K18la | m6A modification | Promote METTL3-mediated m6A modification on ACSL4 | ALI | [72] |
HADHA K519 | Methylation | KDM6B-mediated HADHA demethylation/ lactylation regulates cementogenesis | Periodontitis | [62] |
NSUN2 K508 | m5C modification | Promote GCLC m5C formation | GC | [75] |
Mecp2 K271la | Methylation | Exercise ameliorates atherosclerosis via Mecp2 k271la-H3k36me3/RUNX1 | Atherosclerosis | [124] |
AMPKα lactylation | Phosphorylation | AMPKα lactylation inhibits its phosphorylation | IVDD | [134] |
H3K18la | ACSL4 lactylation | H3K18la promotes ACSL4 transcription, while lactate directly stimulates non-histone lactylation of ACSL4 at K412 | IVDD | [73] |
H3K18la | MTCH2 acetylation | H3K18la-induced ACAT2 transcription promotes MTCH2 K100 acetylation, which disrupts OXPHOS and establishes a positive feedback loop | PC | [84] |
SPRING lactylation | Phosphorylation | pPCK1 binds to and phosphorylates LDHA, further promoting SPRING lactylation at K82 and thereby enhancing MVA pathway activity | ICC | [83] |
