Fig. 3: Derivation of a HGSOC TIS gene signature.
From: Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer
A Heatmap showing core HGSOC TIS signature derived from differentially upregulated and downregulated genes (p-value adjusted < 0.1) between OVCAR3, OVCAR4, OVCAR8, AOCS14 and AOCS30 cells exposed to cisplatin or CX-5461 and their respective vehicle controls. B Bubble plot showing gene set enrichment of senescence signatures for differentially expressed genes between pre- and post-NACT single-cell RNAseq samples. Normalised enrichment score is shown with colour scale indicating p-value for statistical significance and size indicates number of genes. Correlation plot of differentially expressed genes from OVCAR3, OVCAR4, OVCAR8, AOCS14 and AOCS30 cells exposed to C cisplatin or D CX-5461 and post-NACT single cell RNAseq samples with a HGSOC_TIS high score > two median absolute deviations compared to all others. Tables indicate Pearson correlation estimate values and their corresponding p-values for statistical significance.
