Fig. 5: AAV2-FoxO1 mitigates FJOA progression and chondrocyte apoptosis in OGT knockout mice. | Cell Death Discovery

Fig. 5: AAV2-FoxO1 mitigates FJOA progression and chondrocyte apoptosis in OGT knockout mice.

From: O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1

Fig. 5: AAV2-FoxO1 mitigates FJOA progression and chondrocyte apoptosis in OGT knockout mice.

A Schematic diagram of animal experiment. B Illustrative Safranin O/fast green tinting of sections taken from the facet joint cartilage of OGTL/L, OGTCKO, and AAV2-FoxO1 + OGTCKO mice. C OARSI scores of superior and inferior facets. IAP represents the inferior articular process, while SAP denotes the superior articular process. Calibration lines represent 100 μm. D Representative TUNEL staining images of OGTL/L (Ctrl), OGTCKO, and AAV2-FoxO1 + OGTCKO mice at 8 months following TAM-induced OGT ablation and AAV2-FoxO1 enhancement of FoxO1 expression. Blue indicates DAPI and red indicates TUNEL. Calibration lines represent 50 μm. Uncertainty markers: SEM. *P < 0.05. **P < 0.01. ***P < 0.001.

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