Fig. 1: Assessment of the effect of the IL-21/IL-21R signaling pathway on mice infected with APP. | Cell Death Discovery

Fig. 1: Assessment of the effect of the IL-21/IL-21R signaling pathway on mice infected with APP.

From: IL-21-dependent Ly6C+Ly6G+CD4+ T cells found in lung enhance macrophages function against Actinobacillus pleuropneumoniae infection in mice

Fig. 1

A The survival rate of WT and IL-21R−/− mice were observed within 72 h post APP (3.2 ×106 CFU/mouse) infection. B–F WT and IL-21R−/− mice were infected with APP intranasally (1 ×106 CFU/mouse), the (B) clinical scores, C weight loss, D lung index, E lung macroscopic pathological changes, and F HE staining results of pathological sections of lungs were recorded 12 h after infection. G–J After IL-21 supplement, the (G) clinical score, H lung macroscopic pathological changes, I lung bacterial burden, and J lung index were recorded 12 h after APP infection. Scale bar = 100 μm *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, using Mann–Whitney U test. Error bars show means ± SEM.

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