Fig. 2: Atorvastatin improves semen parameters and partially restores the fertility of EAO mice. | Cell Death Discovery

Fig. 2: Atorvastatin improves semen parameters and partially restores the fertility of EAO mice.

From: Atorvastatin improves spermatogenesis in murine and in vitro human chronic orchitis models through restoring blood-testis barriers

Fig. 2: Atorvastatin improves semen parameters and partially restores the fertility of EAO mice.

a Sperm concentration and sperm motility in Vehicle, EAO-Sal and EAO-AT groups, n = 12. b Bright field diagram of 2-cell, 4-cell, morula, and blastocyst derived from sperm in Vehicle, EAO-Sal and EAO-AT groups by in vitro fertilization (IVF). Arrows indicate normal developing embryos. Scale bar, 200 μm. c The trilinear table shows all the embryo preimplantation development data of IVF in Vehicle, EAO-Sal and EAO-AT groups, * indicates Vehicle vs EAO-Sal group and # indicates EAO-Sal vs EAO-AT group, n = 4. d Presence of vaginal plugs (blue boxes) in female mice at childbearing age after timed mating with male mice from Vehicle, EAO-Sal and EAO-AT groups. e Number of pregnant female mice when natural mating with male mice from Vehicle, EAO-Sal and EAO-AT groups for 10 weeks, n = 4. Data are presented as mean ± SEM, */#P < 0.05, ** P < 0.01, ***P < 0.001, ****P < 0.0001.

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