Fig. 1: The link between mitochondria and pyroptosis. | Cell Death Discovery

Fig. 1: The link between mitochondria and pyroptosis.

From: Mitochondrial orchestration of PANoptosis: mechanisms, disease pathogenesis, and emerging therapeutic frontiers

Fig. 1: The link between mitochondria and pyroptosis.The alternative text for this image may have been generated using AI.

The presence of certain intracellular pathogens activates inflammatory caspases, which subsequently activate pro-inflammatory cytokines IL-1β and IL-18. Inflammatory caspase-1 also clears and activates GSDMD, which forms pores in the plasma membrane and penetrates, leading to pyroptosis. Active GSDMD also induced MOMP. In addition, the inflammasome activity cleans and activates the protein BID to induce MOMP. Subsequently, caspase-3 is activated and cleans the glycoprotein pannexin 1, leading to the formation of potassium channels on the plasma membrane and the efflux of potassium ions, which further promotes the formation of the inflammasome.

Back to article page