Fig. 4: Regulatory mechanism of PANoptosis. | Cell Death Discovery

Fig. 4: Regulatory mechanism of PANoptosis.

From: Mitochondrial orchestration of PANoptosis: mechanisms, disease pathogenesis, and emerging therapeutic frontiers

Fig. 4: Regulatory mechanism of PANoptosis.The alternative text for this image may have been generated using AI.

Different pathogens activate specific PANoptosome complexes, which in turn trigger multiple cell death pathways. The upper left is ZBP1-PANoptosome activated by IAV, and the upper right is AIM2-PANoptosome activated by HSV. The lower left also shows Yersinia activating RIPK1-PANoptosome via TNFR/TLR, and the lower right activating NLRP12-PANoptosome via TLR2/4 and MyD88. These complexes interact through different signaling molecules, ultimately leading to multiple forms of cell death such as necroptosis, apoptosis, and pyroptosis.

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