Fig. 9: In vivo overexpression of NCOA7 inhibits the progression of ccRCC. | Cell Death Discovery

Fig. 9: In vivo overexpression of NCOA7 inhibits the progression of ccRCC.

From: NCOA7 inhibits renal cancer progression by inducing autophagy and lipid metabolism through V-ATPase interaction

Fig. 9

A Quantification of tumor volumes. 786-O cells with stable overexpression of NCOA7 are injected into nude mice. Tumor size is measured every 5 days. n = 6. B Images of tumors dissected from the mice are shown. Vector: n = 6; NCOA7-overexpressing: n = 6. C At the conclusion of the experiment, tumors are weighed post-resection. n = 6. D Immunohistochemical (IHC) staining of tumor xenografts from both the NCOA7-overexpressing and control groups were conducted. Scale bar: 50 μm. E Living fluorescence images of the metastasis model in the NCOA7 overexpression and control groups. ns: not significant. *P < 0.05, **P < 0.01, ***P < 0.001. Data are presented as mean ± SD (n = indicated mice per group). Statistical analysis was performed using two-way ANOVA for tumor growth curves (A) and unpaired Student’s t test for tumor weight and quantitative staining results (C, D, E). NCOA7, nuclear receptor co-activator 7.

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