Fig. 2: Elevated GPX2 expression in DGC correlates with poor prognostic outcomes. | Cell Death Discovery

Fig. 2: Elevated GPX2 expression in DGC correlates with poor prognostic outcomes.

From: Targeting GPX2 to disrupt lipid homeostasis and enhance cisplatin sensitivity in diffuse gastric cancer

Fig. 2

A Analysis of GPX2 expression in normal versus tumor tissues using the TCGA-STAD and GTEx databases. B GPX2 expression in normal and tumor tissues from the ACRG dataset. C Determination of GPX2 protein levels in gastric cancer cell lines via Western blot analysis. D Measurement of GPX2 protein levels in tumor tissues and adjacent non-tumor tissues from DGC patients using Western blot. E Immunohistochemical staining of GPX2 in tissue microarray composed of cancerous and adjacent non-cancerous tissues from 160 gastric cancer patients. Scale bars = 50 μm or 200 μm. F Distribution of the difference in immunohistochemistry (IHC) scores (ΔIRS = IRST–IRSN) for GPX2 in tissue microarrays. G Kaplan–Meier survival curves for gastric cancer patients with high and low GPX2 expression. H Univariate Cox regression analysis assessing the prognostic significance of GPX2 expression. I Time-dependent AUC curve of GPX2.

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