Fig. 4: IL-1β promoted vemurafenib resistance through enhancing melanoma cell viability. | Cell Death Discovery

Fig. 4: IL-1β promoted vemurafenib resistance through enhancing melanoma cell viability.

From: LINC01198 activates Hippo signaling to stimulate IL-1β autocrine for driving vemurafenib resistance by associating with TAOK1/2 in melanoma

Fig. 4: IL-1β promoted vemurafenib resistance through enhancing melanoma cell viability.

A EdU assays were conducted after treatments with vemurafenib together with 50 ng/mL or 200 ng/mL of IL-1β respectively. B Colony formation assay in A375R cells treated with vemurafenib and/or IL-1β. The level of IL-1β was detected by Western blot after IL1B knockdown C and overexpression E. Measurements of relative cell viability by CCK-8 assay in A375R cells treated with 2 μM vemurafenib after IL1B knockdown D and overexpression F. G EdU assay detected cell viabilities after treatments with vemurafenib and IL-1β or LINC01198 knockdown. Data are presented as the means ± SD and p values are determined using two-tailed Student’s t-test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.

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