Fig. 9: LINC01198 and IL1B are higher-expressed in melanoma patients unresponsive to vemurafenib treatment. | Cell Death Discovery

Fig. 9: LINC01198 and IL1B are higher-expressed in melanoma patients unresponsive to vemurafenib treatment.

From: LINC01198 activates Hippo signaling to stimulate IL-1β autocrine for driving vemurafenib resistance by associating with TAOK1/2 in melanoma

Fig. 9: LINC01198 and IL1B are higher-expressed in melanoma patients unresponsive to vemurafenib treatment.

A Expression levels of LINC01198 in vemurafenib responsive and non-responsive melanoma patients. B Expression levels of IL1B in vemurafenib responsive and non-responsive melanoma patients. C Correlation analysis between LINC01198 and IL1B gene expression. D A model depicts that LINC01198 enhances the resistance of melanoma to vemurafenib by associating with TAOK1/2 to activate Hippo signaling and transcriptionally elicit IL-1B expression. Data are presented as the means ± SD and p values are determined using two-tailed Student’s t-test. * p < 0.05; ** p < 0.01; *** p < 0.001.

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