Fig. 6: The regulatory role of STING in tumor-induced bone destruction via OPN formation relies on the inhibition of IL-6. | Cell Death Discovery

Fig. 6: The regulatory role of STING in tumor-induced bone destruction via OPN formation relies on the inhibition of IL-6.

From: Therapeutic targeting of STING-IL6/STAT3 axis to inhibit osteoclastic niche formation and breast cancer bone metastasis

Fig. 6: The regulatory role of STING in tumor-induced bone destruction via OPN formation relies on the inhibition of IL-6.

A Representative radiographs of long bones hosting tumors from mice treated with vehicle or CM, where CM was derived from tumor cells infected with lentivirus expressing STING as needed. The yellow arrows indicate sites of bone destruction. B Ratio of bone fractures on day 21 after injection of cancer cells. n = 6 per group. C Micro-CT images showing trabecular and cortical bone destruction in the proximal tibia. D Morphometric quantification of cortical bone micro-CT images with analysis of BV/TV from different groups. n = 6 per group. E Micro-CT images showing bone destruction on the surface of the vertebral bodies. The yellow arrows indicate sites of bone destruction. Data are presented as mean ± SD. Significance levels are indicated on top of each comparison. P values were calculated using a two-way ANOVA with a multiple comparisons test.

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