Fig. 3: CREB5 promotes lymphangiogenesis in CCa.
From: CREB5 promotes nodal metastasis of cervical cancer by regulation of APLN-induced lymphangiogenesis
A, B Representative immunostaining images of D2-40 (lymphatic endothelial marker) in peritumoral and intratumoral regions of xenograft tumors from shGFP and shCREB5 groups. C–F Quantification of lymphatic vessel density (LVD) in peritumoral (C, D) and intratumoral (E, F) regions. G, H Representative images of tube formation (G) and transwell migration (H) assays for HLECs treated with conditioned medium from (CM) shGFP or shCREB5 CCa cells. I, J Quantitative analysis of tube length (I) and migrated HLECs (J). K Western blot analysis of total AKT and phosphorylated AKT (pAKT) in HLECs treated with CM from shCtrl or shCREB5 CCa cells.
