Fig. 1: GSVA at the single-cell level reveals SLC7A1-related biological processes.
From: Identification of SLC7A1 as a potential therapeutic target for high-grade meningioma
A tSNE plot of 32714 cells with each cell color-coded by cell type. B tSNE plots of 19429 meningioma cells with each cell color-coded by cell cluster. C Violin plot displaying the expression levels of ASS1, ASL, SLC7A1, SLC7A2, and SLC7A3 in different clusters of meningioma cells. D tSNE plots of 19429 meningioma cells with each cell color-coded by the expression level of SLC7A1. E The effect of CRISPR knockout of SLC7A1, SLC7A2, and SLC7A3 in pan-cancer from the DEPMAP portal. F Differences in pathway activities scored per cell by GSVA between high- and low-SLC7A1 meningioma cell clusters. G–I tSNE plots of 19429 meningioma cells with each cell color-coded by GSVA score of the MYC targets, G2M checkpoint, and E2F targets pathways. J GSEA at the bulk level displaying the activation of MYC targets, G2M checkpoint, and E2F targets pathways in the high-SLC7A1 group of the GSE136661 dataset.
