Fig. 1: The NEDD8-activating enzyme (NAE1) is upregulated in RMS patients, and FP-RMS cells are dependent on its functions. | Cell Death Discovery

Fig. 1: The NEDD8-activating enzyme (NAE1) is upregulated in RMS patients, and FP-RMS cells are dependent on its functions.

From: Neddylation inhibition induces DNA double-strand breaks, hampering tumor growth in vivo, and promotes radiosensitivity in PAX3–FOXO1 rhabdomyosarcoma

Fig. 1

A, B Floating bars plot for NAE1 and UBA3 CRISPR depletion across several tumor types from Achilles project (24Q2 DepMap, https://depmap.org/portal/achilles/). Floating bars depict minimum and maximum Chronos score values, and the black line in the bar shows the median. The full line is set at a score of 0 (not essential gene), and the dashed line is set at a score of −0.5 (essential gene). C Violin plot depicts MLN4924 drug response in different cell lines from drug sensitivity AUC (CTD2) (24Q2 DepMap, https://depmap.org/portal/). AUC area under the curve.

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