Fig. 4: MLN4924 prevents PAX3–FOXO1 RMS tumor growth in vivo. | Cell Death Discovery

Fig. 4: MLN4924 prevents PAX3–FOXO1 RMS tumor growth in vivo.

From: Neddylation inhibition induces DNA double-strand breaks, hampering tumor growth in vivo, and promotes radiosensitivity in PAX3–FOXO1 rhabdomyosarcoma

Fig. 4

A Images of RH4 and RH30 xenografted tumors explanted from mice treated for 3 weeks with either vehicle or MLN4924 50 mg/kg. B Volume of RH4 and RH30 xenografted tumors treated as in (A) (vehicle n = 6, MLN4924 n = 6). Data presented the mean ± SEM. Two-way ANOVA. Exact p-values are reported in the figure. C Box plot depicts the weight of RH4 and RH30 xenografted tumors explanted from mice treated as in (A). Box plots represent 25th to 75th quartiles, the black bar depicts the median, and whiskers go to the lower quartile and then to the upper quartile. Two-way ANOVA. Exact p-values are reported in the figure. D Representative images of H&E, p27, p21, Cleaved Caspase, and Ki67 immunohistochemistry of tumor sections from RH4 and RH30 xenografts explanted from mice treated as in (A). Scale Bars = 100 μm. E Histograms depict the quantification of the Area fraction of the immunohistochemistry staining reported in (D). Graph represents the mean ± SD (n = 3 independent tumor sections). Two-tailed t-test. Exact p-values are reported in the figure.

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