Fig. 1: The effects of 3 antitumor drugs on hepatocellular carcinoma (HCC) cell lines pretreated with or without heat. | Cell Death Discovery

Fig. 1: The effects of 3 antitumor drugs on hepatocellular carcinoma (HCC) cell lines pretreated with or without heat.

From: Tanshinone IIA inhibits heat-induced growth of p53-mutant Huh-7 hepatocellular carcinoma by modulating osmotic homeostasis and glycolysis through targeting ALDH7A1

Fig. 1: The effects of 3 antitumor drugs on hepatocellular carcinoma (HCC) cell lines pretreated with or without heat.

A, B The viability of HCC cell lines Huh-7 and Hep-G2, pretreated with heat at various temperatures—37 °C, 44 °C, 45 °C, 46 °C, and 47 °C, respectively—was assessed after being reinoculated and cultured in new culture media at 37 °C. C–H The viability of Huh-7 and Hep-G2 cells following treatment with various concentrations of 3-BrPA (3-bromopyruvate), As2O3, or Tanshinone IIA (Tan IIA) as indicated. I, J The inhibitory effects of different antitumor drugs on HCC cells pretreated at 44 °C. For (A–H), *p < 0.05, **p < 0.01, compared with 37 °C at the same time point; the same color indicates the same group. For (I–J), **p < 0.01, Tan IIA/8 μM vs NC; ## p < 0.01, 3-BrPA/40 μM vs NC; ++ p < 0.01, As2O3/6 μM vs NC; all comparisons were performed on data at the same temperature. NS not significant.

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