Fig. 3: Normalizing DEPTOR protein levels in FGR PHT cells restores the mTORC1 signaling. | Cell Death Discovery

Fig. 3: Normalizing DEPTOR protein levels in FGR PHT cells restores the mTORC1 signaling.

From: Normalization of trophoblast mTOR signaling rescues impaired function in primary human trophoblast cells isolated from pregnancies complicated by fetal growth restriction

Fig. 3: Normalizing DEPTOR protein levels in FGR PHT cells restores the mTORC1 signaling.

a, c Representative Western blot for S6-Ser 235/236 and total S6 in cell lysates of AGA and FGR PHT cells transfected with either scramble or DEPTOR siRNA. b, d Histogram summarizes the Western blotting data. Equal loading was performed. After normalization to total protein, the mean density of AGA samples was assigned an arbitrary value of 1. Values are given as means ±  sem. *P < 0.05 vs. AGA PHT cells transfected with scramble siRNA; Means without a common letter differ significantly (P  < 0.05) by One-way ANOVA with Tukey–Kramer multiple comparisons post hoc test.

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