Fig. 4: Tryptase affects chromatin organization in breast cancer cells.
From: Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
Hs578T cells were cultured for 48 h under normal conditions (Control) or with 50 nM tryptase. Transmission electron microscopy (TEM) images of control- and tryptase-treated cells. In control cells, the nuclear envelope is intact (red arrow) and nuclear pores are visible (yellow arrow). In tryptase-treated cells, the nuclear envelope appears less defined (red arrow) with fewer nuclear pores and chromatin exhibiting a fibrillar-like structure (white arrow). The lower panel shows quantifications of the diameters of fibrillar-like chromatin, compatible with a beads-on-a-string organization.
