Fig. 5: Tryptase-positive MCs are present in PyMT murine breast cancer tumours and human triple-negative breast cancer.
From: Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
Confocal Z-stack images stained with Hoechst 33342 (blue), tryptase (green) and Ki67 (red) were used to generate 3D-images of PyMT murine breast cancer tumour sections (A-D), healthy mammary tissue (E) and human triple-negative breast cancer tumours (F, G). A PyMT tumour tissue lacking MCs. B Reduced Ki67 positivity near tryptase-positive MCs. C Nuclear localization of tryptase within tumour cells (yellow arrows). D Ki67-positive MCs detected within the tumour (yellow arrow). E Healthy human breast tissue. F Human breast cancer tumour section lacking MCs. G Tumour tissue with reduced Ki67 positivity near tryptase-positive MCs.
