Fig. 4: The dynamic expression of related genes in the process of metastasis and the correlation with patient prognosis. | Cell Death Discovery

Fig. 4: The dynamic expression of related genes in the process of metastasis and the correlation with patient prognosis.

From: Single-cell and spatial dissection of necroptosis spatiotemporal evolution driving lymph node metastasis in gastric cancer

Fig. 4: The dynamic expression of related genes in the process of metastasis and the correlation with patient prognosis.The alternative text for this image may have been generated using AI.

A Dot plots of dynamic expression of key genes in DAMPs and Necroptosis and the two pathways themselves based on KEGG database along two cell fates. B Prognostic and clinicopathologic correlation of necroptosis related genes in gastric adenocarcinoma (TCGA cohort, n = 407). Kaplan–Meier curves showed that patients with high necroptosis related genes expression had significantly shorter overall survival. Elevation of necroptosis related genes expression was associated with advanced N stage. C Immunofluorescence staining of CHMP3 green in PT and MLN and paracancerous issues. Cell nuclei were counterstained with DAPI (blue). Scale bar: 100 μm. D Spatial transcriptomic localization of CHMP3, where the regions marked by red lines are tumor tissues and the rest are tumor stroma.

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