Fig. 7: Spatial and molecular dynamics of gastric cancer metastasis revealed by integrated ST. | Cell Death Discovery

Fig. 7: Spatial and molecular dynamics of gastric cancer metastasis revealed by integrated ST.

From: Single-cell and spatial dissection of necroptosis spatiotemporal evolution driving lymph node metastasis in gastric cancer

Fig. 7: Spatial and molecular dynamics of gastric cancer metastasis revealed by integrated ST.The alternative text for this image may have been generated using AI.

A UMAP plots from four primary gastric cancer ST data. Each cluster is shown in a different color. B Spatial annotation of tumor and stromal regions. Left: H&E staining of a gastric cancer section from patient T1. The blue part is the tumor region. Middle: The pie chart shows the composition of cell type occupancy for each spatial SPOT (scale bar: 500 μm). Right: proportions of non-metastatic cells (red), metastatic cells (blue) and other types of cells (green) relative to each other. C Tumor progression trajectory analysis. The arrows show the line of the progression trajectory of gastric cancer (right), and the necroptosis score and EMT score, and immunity score along the trajectory region (left). D MDK-NCL signaling profile. Left: midkine (MDK) is enriched in the tumor region. Middle panel: nucleolin (NCL) is enriched in the stromal region. Right: MDK-NCL signaling is enriched at the tumor-stroma interface.

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