Fig. 2: Metformin prevents RGC loss induced by retinal ischemia/reperfusion injury and preserves retinal morphology. | Cell Death Discovery

Fig. 2: Metformin prevents RGC loss induced by retinal ischemia/reperfusion injury and preserves retinal morphology.

From: Metformin protects retinal ganglion cells in a preclinical model of retinal ischemia/reperfusion injury and stabilizes visual field in diabetic patients with glaucoma

Fig. 2

A Representative fluorescent photomicrographs of FluoroGold-labeled RGCs in mid-peripheral retina from control (C) and ischemic (I) retinas of vehicle- or metformin-treated mice. Scale bar 75 μm. B Quantitative analysis of RGC density in peripheral, middle and central retina from metformin- (10, 50 mg/kg) or vehicle-treated mice. Ischemia was induced in the right eye (I); left eye was used as control (C). Results are reported as mean ± s.e.m. (n = 3). *p < 0.05. C Representative hematoxilin and eosin-stained retinal sections from mice treated with metformin 10 mg/kg or vehicle. GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, ONL outer nuclear layer, OPL outer plexiform layer. (Met metformin).

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