Fig. 9: Schematic diagram of MSLN-EGFR-ERK signaling contributing to breast cancer liver metastasis. | Cell Death Discovery

Fig. 9: Schematic diagram of MSLN-EGFR-ERK signaling contributing to breast cancer liver metastasis.

From: MSLN-mediated activation of EGFR-ERK1/2 signaling drives liver metastasis in breast cancer

Fig. 9: Schematic diagram of MSLN-EGFR-ERK signaling contributing to breast cancer liver metastasis.

The transcription factor ELF1 in hepatotropic metastatic cancer cells causes an increased MSLN. The elevated MSLN interacts with EGFR, resulting in phosphorylation of EGFR as well as the activation of downstream ERK1/2 signaling pathway, thereby promoting disseminated TNBC cell survival and proliferation, thus lead to liver metastasis.

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