Fig. 7: Regulation of TKT to RCC cells metastasis and proliferation is dependent on PKM2. | Cell Death Discovery

Fig. 7: Regulation of TKT to RCC cells metastasis and proliferation is dependent on PKM2.

From: TKT drives renal cell carcinoma progression through metabolic reprogramming and synergistic interaction with PKM2

Fig. 7: Regulation of TKT to RCC cells metastasis and proliferation is dependent on PKM2.The alternative text for this image may have been generated using AI.

A Transwell assays assessing the impact of PKM2 knockdown on TKT-driven RCC cell migration, invasion. B Wound healing assays demonstrating that PKM2 knockdown significantly reverses TKT-driven wound closure in RCC cells. C CCK-8 assays assessing the impact of PKM2 knockdown on TKT-driven RCC cell proliferation. Relative statistical results of CCK-8 assays are as following. In 786-O cells, Day 2: Ctrl vs TKT: ***; Ctrl vs siPKM2 #1: ***; Ctrl vs siPKM2 #2: ***; TKT vs TKT+ siPKM2 #1: ***; TKT vs TKT+ siPKM2 #2: ***. Day 3: Ctrl vs TKT: ***; Ctrl vs siPKM2 #1: ***; Ctrl vs siPKM2 #2: ***; TKT vs TKT+ siPKM2 #1: ***; TKT vs TKT+ siPKM2 #2: ***. Day 4: Ctrl vs TKT: ***; Ctrl vs siPKM2 #1: ***; Ctrl vs siPKM2 #2: ***; TKT vs TKT+ siPKM2 #1: ***; TKT vs TKT+ siPKM2 #2: ***. In ACHN cells, Day 2: Ctrl vs TKT: ***; Ctrl vs siPKM2 #1: ***; Ctrl vs siPKM2 #2: ***; TKT vs TKT+ siPKM2 #1: ***; TKT vs TKT+ siPKM2 #2: ***. Day 3: Ctrl vs TKT: ***; Ctrl vs siPKM2 #1: ***; Ctrl vs siPKM2 #2: ***; TKT vs TKT+ siPKM2 #1: ***; TKT vs TKT+ siPKM2 #2: ***. Day 4: Ctrl vs TKT: ***; Ctrl vs siPKM2 #1: ***; Ctrl vs siPKM2 #2: ***; TKT vs TKT+ siPKM2 #1: ***; TKT vs TKT+ siPKM2 #2: ***. *P < 0.05, **P < 0.01, ***P < 0.001.

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