Fig. 4: Clinical cohort demonstrated that TREM1+ Mφ, pyroptotic epithelial cells, and pathogenic Th17 cells could increase the risk of the inflammatory development of oral mucosal epithelium. | Cell Death Discovery

Fig. 4: Clinical cohort demonstrated that TREM1+ Mφ, pyroptotic epithelial cells, and pathogenic Th17 cells could increase the risk of the inflammatory development of oral mucosal epithelium.

From: Epithelial pyroptosis-induced TREM1+ macrophages activate Th17 cells to accelerate oral mucosal inflammation

Fig. 4

a Flow chart of the establishment of the clinical follow-up cohort. b Top, radar plot of cell type fraction in the inflammatory development of oral mucosal epithelium based on BayesPrism deconvolution. Bottom, barplot of the upregulated signaling pathways in the REOLP through ssGSEA. c Box plots show the expression of cell markers in the inflammatory development of oral mucosal epithelium. d Density plots exhibiting the correlation of cell markers in pyroptotic epithelial cells, TREM1+ Mφ, and pathogenic Th17 cells in the inflammatory development of oral mucosal epithelium. Red: REOLP. Blue: NREOLP. e Univariate logistic regression model revealing the risk factors of the inflammatory development of oral mucosal epithelium. f PCA biplot of marker gene expression. Arrows represent gene loading vectors, colored by contribution magnitude (contribution 12–16; color bar). g Scree plot of condition indices for collinearity diagnostics. Horizontal dashed lines indicate thresholds for severe (red, >30) and moderate (orange, >15) multicollinearity.

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