Fig. 6: ORGUAMIA database uncovered that TREM1⁺ Mφ participated in the inflammatory development of chronic digestive disorders.

A Schematic of the establishment of the ORGUAMIA database. The role of epithelial pyroptosis-induced TREM1⁺ Mφ in periodontitis (PD) datasets (B) and IBD datasets (C). Left, UMAP plot of cell colors by cell types, myeloid cell types, and epithelial cell types. Middle, Histogram showing the cell proportions of myeloid cell types (top) and epithelial cell types with disease subtypes (bottom). Top right, violin plot showing the IL1B expression in Mφ subtype. Bottom right, circle plot of the intercellular communication from pyroptotic epithelial cells to other cells. Line width, the intercellular communication strength. Red arrow, the intercellular communication strength in PD/IBD was higher than in normal. Blue arrow, the intercellular communication strength in normal was higher than in PD/IBD.