Table 2 Classification of deacetylases.
From: Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation
Classification | Subcellular localization | |||
|---|---|---|---|---|
Deacetylase | Classical deacetylases (Zn2+-dependent) | I | HDAC1 | Nucleus |
HDAC2 | Nucleus | |||
HDAC3 | Nucleus | |||
HDAC8 | Nucleus | |||
IIa | HDAC4 | Nucleus | ||
HDAC5 | Nucleus | |||
HDAC7 | Nucleus | |||
HDAC9 | Nucleus | |||
IIb | HDAC6 | Cytoplasm | ||
HDAC10 | Cytoplasm | |||
IV | HDAC11 | Nucleus | ||
Sirtuin deacetylases (NAD+-dependent) | III | SIRT1 | Nucleus | |
SIRT2 | Cytoplasm | |||
SIRT3 | Mitochondria | |||
SIRT4 | Mitochondria | |||
SIRT5 | Mitochondria | |||
SIRT6 | Nucleus | |||
SIRT7 | Nucleolus | |||
Other | TCF1 | Nucleus | ||
LEF1 | Nucleus |
