Fig. 6: The p53 tumor suppressor pathway showed functional heterogeneity in uveal melanoma.

A A summary of the p53 pathway functionality and p53 isoform expression in our panel of 10 UM cell lines. B A graphical representation of the impact of p53 isoforms altered expression on the p53-dependent transcriptional regulation and the influence on downstream pathways. Created with BioRender.com.