Fig. 5: EIF2AK3 modulated PI3K/AKT signaling independently of mTOR in NSCLC cells. | Cell Death Discovery

Fig. 5: EIF2AK3 modulated PI3K/AKT signaling independently of mTOR in NSCLC cells.

From: Hypoxia-triggered autophagy modulates cisplatin resistance in non-small cell lung Cancer via EIF2AK3-dependent PI3K/AKT signaling and mTOR-independent mechanisms

Fig. 5: EIF2AK3 modulated PI3K/AKT signaling independently of mTOR in NSCLC cells.The alternative text for this image may have been generated using AI.

A549 and 95D cells were transduced with sh-EIF2KA3 or Ov-EIF2AK3 and then exposed to hypoxia for 24 h. Western blot analysis was performed to assess the protein expression of PI3K, p-PI3K, AKT, p-AKT, mTOR, and p-mTOR in A549 (A) and 95D (B) cells. Data are presented as mean ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 versus sh-NC; #p < 0.05, ##p < 0.01 versus Ov-NC.

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