Fig. 1: PFKFB3 plays an important role in the development of osteoarthritis (OA).
From: The glycolytic enzyme PFKFB3 alleviates DNA damage and chondrocyte senescence in osteoarthritis
a Safranin O-Fast Green (SO&FG) staining (Left) and immunohistochemical (IHC) staining of PFKFB3, COL2A1, and MMP13 in human normal and OA cartilage. b Mankin scores and quantification of PFKFB3, COL2A1, and MMP13 signals in human non-OA and OA cartilage. Data presented as means ± s.e.m., n = 6, unpaired Student’s t-test. c SO&FG staining and IHC staining in the cartilage of 2-month-old, 10-month-old, and 18-month-old mice. d Osteoarthritis Research Society International (OARSI) scores and quantification of PFKFB3, COL2A1, and ACAN expression in the cartilage of aged mice. Data presented as means ± s.e.m., n = 6, one-way ANOVA with Tukey’s comparisons. e SO&FG staining and IHC staining in the cartilage of mice subjected to 8 weeks after DMM surgery. f OARSI scores and quantification of PFKFB3, COL2A1, and MMP13 signals in the cartilage of mice subjected to DMM surgery. Data presented as means ± s.e.m., n = 6, unpaired Student’s t-test. *P < 0.05, **P < 0.01. ns not significant.
