Fig. 7: PFKFB3 alleviates chondrocyte DNA damage and senescence in osteoarthritis. | Cell Death Discovery

Fig. 7: PFKFB3 alleviates chondrocyte DNA damage and senescence in osteoarthritis.

From: The glycolytic enzyme PFKFB3 alleviates DNA damage and chondrocyte senescence in osteoarthritis

Fig. 7

PFKFB3 is critical in cartilage under physiological conditions by inhibiting NF-κB activation and promoting DNA repair. In the progression of osteoarthritis, reduced PFKFB3 expression activates the NF-κB signaling pathway and impairs DNA repair, leading to increased levels of proinflammatory factors, as well as accumulated DNA damage and chondrocyte senescence.

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