Fig. 5: Volcano plot of RNA-Seq analysis in wild type and TLR3W769* hLORGs infected with VSV-pseudo SARS-CoV-2 virus.

A The Volcano plot illustrates the significant mRNAs that we identified as down-regulated in wild type and TLR3W769* hLORGs before infection, positioned on the left (down-regulated) and above the vertical line (statistically significant), based on significant -log(10)padj and log2fold-change. B The Volcano plot depicts the significant mRNAs that we discovered to be down-regulated in wild type and TLR3W769* hLORGs following infection, placed on the left (down-regulated) and above the vertical line (statistically significant), according to significant −log(10)padj and log2fold-change. The vertical lines indicate no change in gene expression (log2fold-change |1 | = 0). The red dotted lines represent an established threshold or boundary for fold change, with a default setting of 2. The solid vertical line signifies a selected threshold for the −log(10)padj and statistical significance, with the default setting set at 0.05. Statistical significance versus fold change is illustrated on the y- and x-axes, respectively.