Fig. 7: Expression of TLR3 in wild type and TLR3W769* hLORGs.
From: Modelling severe COVID-19 in TLR3-mutated hiPSCs-derived lung organoids
A Relative mRNA expression of TLR3 genes in wild type and TLR3W769* hLORGs after 48 hpi with SARS-CoV-2 and without (NT) virus. The bar graph shows the expression of TLR3 genes quantified by qRT-PCR. The results are represented as the mean ± SEM (*p < 0.05; ***p < 0.001; ****p < 0.0001; by one-way ANOVA test, n = 3). B Blot and densitometric analysis of TLR3 protein in wild type and TLR3W769* hLORGs hLORGs after 48 hpi with SARS-CoV-2 and without (NT) virus. The average was evaluated in at least two independent experiments and is reported as means ± SEM; (* p < 0.05 and ** p < 0.01 estimated by a one-way ANOVA test, n = 2). Abbreviations: hpi hours post-infection, ADU arbitrary densitometric units.
