Fig. 8: Angiogenesis in HCC with high APOA2 expression is TGF-β dependent sensitive to TGF-β inhibitors, and more sensitive to PD-1/TGF-β dual antibodies. | Cell Death Discovery

Fig. 8: Angiogenesis in HCC with high APOA2 expression is TGF-β dependent sensitive to TGF-β inhibitors, and more sensitive to PD-1/TGF-β dual antibodies.

From: APOA2-mediated endothelial mesenchymal transition and cancer lipid metabolism reprogramming confers antiangiogenic drug resistance through TGF-β

Fig. 8: Angiogenesis in HCC with high APOA2 expression is TGF-β dependent sensitive to TGF-β inhibitors, and more sensitive to PD-1/TGF-β dual antibodies.The alternative text for this image may have been generated using AI.

a Western blotting detecting the protein levels of Snail, N-cadherin, VEGFR2 in HUVEC in the designated group. b Relative mRNA level of Snail in HUVEC in the designated group was analyzed by real-time quantitative PCR (n = 6). c Subcutaneous tumor, tumor volume, and tumor mass quantification of each group (n = 6). d Representative images of CD31 and VEGFR2 immunofluorescence staining of tumor tissue, with CD31+ andVEGFR2+ signals quantified from 12 fields (n = 6). Scale bars, 40 µm. e Assessment of subcutaneous tumor growth, tumor volume, and tumor mass for each group treated with GW, GW788388 (TGF-β inhibitors), anti-PD-1 (anti-mouse PD-1 antibody), and JS201-Sur (mouse PD-1/TGF-β dual antibody) (n = 6). *p < 0.05, ns, not significant.

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