Fig. 6: BACH2 suppresses migration of primary adult human cardiac fibroblasts and inhibits the expression of profibrotic POSTN. | Cell Death Discovery

Fig. 6: BACH2 suppresses migration of primary adult human cardiac fibroblasts and inhibits the expression of profibrotic POSTN.

From: BACH2 links β1-adrenergic receptor/β-arrestin1 signaling to MIAT to inhibit cardiac fibroblast activation and cardiomyocyte apoptosis

Fig. 6: BACH2 suppresses migration of primary adult human cardiac fibroblasts and inhibits the expression of profibrotic POSTN.

A–C HCFs, which were transfected with si-control or si-BACH2, were subjected to H/R. Scratch migration assays were then performed. Initial open areas (0 h; H) were measured to serve as total open area, and the % of open area after 24 H was calculated to quantify migratory potential. D HCFs were transfected as indicated above. QRT-PCR analyses of POSTN were then performed. Data are shown as the fold induction of gene expression normalized to GAPDH. N = 6 per group. Two-way ANOVA with Tukey’s multiple comparison test. *P < 0.05 or **P < 0.01 vs. si-control. ##P < 0.01 or ###P < 0.001 vs. normoxia. Data are presented as the mean ± SEM.

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