Table 1 .IC50 values of sotorasib and fulzerasib in KRASG12C and non-KRASG12C cell lines.
Inhibitor | Cell line | IC50 (nM) 10%FBS without hEGF | IC50 (nM) 0.5%HS without hEGF (10 ng/mL) | IC50 (nM) 0.5%HS with hEGF (10 ng/mL) |
|---|---|---|---|---|
Sotorasib | H23 | 10,214.0 | 12,500a | >25,000a |
H358 | <5.0 | <5.0a | 85.1a | |
H2122b | 7.1 | 612.5a | >25,000a | |
H1792 | 55.6 | 9731.5 | 11,024.8 | |
MIA PaCa-2 | 3513.8 | 9002.0 | 15,644.0 | |
H2030 | >25,000 | 13,763.9 | 23,296.8 | |
A549 | >25,000 | - | - | |
H1819 | >25,000 | - | - | |
SK-MES-1 | >25,000 | - | - | |
Fulzerasib | H23 | 2470.0 | 1597.0 | 2178.0 |
H358 | 6.3 | <5.0 | 28.4 | |
H2122b | 33.6 | <5.0 | 52.0 | |
H1792 | 50.9 | 1270.0 | 6067.0 | |
MIA PaCa-2 | 2907.0 | 8163.0 | 9578.0 | |
H2030 | >25,000 | 13,143.0 | >25,000 | |
A549 | 19,356.0 | - | - | |
H1819 | 19,427.4 | - | - | |
SK-MES-1 | >25,000 | - | - |
