Fig. 2: GQ20 forms quadruplexes (G4) and is taken up by cells. | Cell Death Discovery

Fig. 2: GQ20 forms quadruplexes (G4) and is taken up by cells.

From: Discovery of synthetic G-quadruplex DNA as SARS-CoV-2 helicase inhibitor with antiviral, anti-inflammatory and antioxidative properties

Fig. 2: GQ20 forms quadruplexes (G4) and is taken up by cells.

A Scheme of experimental endpoints. B Binding of Cy3-labeled GQ20-PTO, GQ20-PDE, and CpG-1-PTO to BG4, an antibody recognizing G4, demonstrated by in vitro gel shift assays. The complex between ODN and BG4 is indicated (GQ). C Quantitative uptake of 1 µM Cy3-labeled GQ20-PTO and GQ20-PDE into Calu-3 cells. Graph displays the relative Cy3/Hoechst 33324 intensity; P values are indicated. D confocal images taken after 24 h. scale bar: 10 µm.

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