Fig. 2: The effect of oseltamivir and linezolid combination treatment on co-infection mice. | Cell Death Discovery

Fig. 2: The effect of oseltamivir and linezolid combination treatment on co-infection mice.

From: Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection

Fig. 2: The effect of oseltamivir and linezolid combination treatment on co-infection mice.The alternative text for this image may have been generated using AI.

A Body weight changes of different groups were recorded for five days. Body weight changes are normalized to the average body weight in each group on the first day and multiply by 100% (n = 6). B Lung index was calculated in different groups (n = 6). Lung index = lung weight of mice (mg)/body weight of mice (g). C Representative pathological images (Scale bars: above 200 μm; below 100 μm) of lung tissue in different groups. Stain areas of images were calculated using image j and then normalized to the average area of the control group (n = 3). D Inflammatory cytokines IL-1β, TNF-α, and CXCL-2 mRNA levels were measured by qRT-PCR. Data are normalized to β-actin and presented as fold of gene expression in the infected groups compared to the control. Data are mean ± standard error of the mean (ns p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001). IAV Influenza virus, MRSA methicillin-resistant S. aureus, Ost oseltamivir, Lzd linezolid.

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