Fig. 4: Macrophage pyroptosis was induced by co-infection and clearance of macrophage could reduce cell late apoptosis and necroptosis. | Cell Death Discovery

Fig. 4: Macrophage pyroptosis was induced by co-infection and clearance of macrophage could reduce cell late apoptosis and necroptosis.

From: Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection

Fig. 4: Macrophage pyroptosis was induced by co-infection and clearance of macrophage could reduce cell late apoptosis and necroptosis.The alternative text for this image may have been generated using AI.

A Flow cytometry analysis of the proportions of F4/80+ CD11b+ recruitment macrophage in pulmonary after 6 h co-infection and B after 48 h co-infection. C Macrophages were deleted by clodronate liposomes which were administrated intranasally or intraperitoneally. D Flow cytometry analysis of Annexin V+ PI+ ‌late apoptosis and ‌necroptosis cells. (n = 4) E Flow cytometry analysis of caspase-1+ PI+ pyroptosis macrophage in different groups after 6 h co-infection and F after 48 h co-infection. Data are mean ± standard error of the mean (*p < 0.05; **p < 0.01; ***p < 0.001) (n = 4). IAV Influenza virus, MRSA methicillin-resistant S. aureus, CL clodronate liposomes.

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