Fig. 1: EAE induces widespread reprogramming of the PFC transcriptome. | Cell Death Discovery

Fig. 1: EAE induces widespread reprogramming of the PFC transcriptome.

From: Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis

Fig. 1: EAE induces widespread reprogramming of the PFC transcriptome.

A Schematic representation of the experimental design. B Graph showing the percentage of regulated and unregulated genes in the PFC of EAE mice compared with controls (CTRL)s. (C) Pie chart showing the percentages of upregulated (red) and downregulated (green) genes in the PFC of EAE mice. D, E Gene Set Enrichment Analysis (GSEA) of the samples of PFC EAE mice vs CTRL. Annotations of upregulated (F–H) and downregulated (I–K) genes in the PFC of EAE mice, respectively in Reactome Pathways 2024 (F, I), Biological Process 2023 (G, J), DisGeNET (H, K) databases. L, M Bar graphs showing qPCR analyses of the expression of selected upregulated (L) and downregulated (M) genes in the PFC of CTRL and EAE mice. Student’s t Test; p < 0.05. All values are given as means ± SD.

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