Fig. 3: High inflammation leads to widespread alteration of MS-associated genes in the prefrontal cortex (PFC). | Cell Death Discovery

Fig. 3: High inflammation leads to widespread alteration of MS-associated genes in the prefrontal cortex (PFC).

From: Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis

Fig. 3: High inflammation leads to widespread alteration of MS-associated genes in the prefrontal cortex (PFC).

A Pie charts showing upregulated (red) and downregulated (green) genes in the PFC of EAE-H and EAE-L mice. B Annotation of differently expressed genes (DEGs) in the DisGeNet catalogue database performed using the ENRICHR tool (https://maayanlab.cloud/Enrichr/enrich) in both EAE subgroups. C Venn diagrams of MS-associated lists of genes from the DisGeNet database showing overlap between the EAE-H and EAEL subgroups. D Boxplots showing distribution and statistical significance of fold change variations of reads related to DEGs in EAE-H and EAE-L subgroups vs controls (CTRL). E Bar graphs showing qPCR analyses of the indicated representative MS-associated genes that are common to both subgroups of EAE samples (One-way ANOVA, Tukey post hoc test, p < 0.05). All values are given as means ± SD. F, H Cell Markers annotations for MS-associated DEGs common to both subgroups (F) and genes exclusively modulated in the EAE-H subgroup (G). H Cellular component annotations of MS-associated genes showing changes exclusively in the EAE-H subgroup.

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