Fig. 6: Expression of specific inflammatory markers correlates with cognitive performances in EAE mice. | Cell Death Discovery

Fig. 6: Expression of specific inflammatory markers correlates with cognitive performances in EAE mice.

From: Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis

Fig. 6: Expression of specific inflammatory markers correlates with cognitive performances in EAE mice.

A Schematic representation of the Object in Place (OIP) test. B Bar graphs show the discrimination ratio scored by control (CTRL; n = 8) and EAE (n = 18) mice in the OIP test. A highly significant reduction is evident in EAE mice compared to CTRLs (Student’ s t test, p < 0.0001). C, D Pearson’s correlation analyses of the expression levels of selected genes in the PFC of EAE mice and the discrimination ratio scored by the same mice in the OIP test. While a significant inverse correlation is evident for the inflammatory genes Cd74, C1qb and C1qc (C), no significant correlation is detectable between other inflammatory markers, such as Ccl2, or the neuronal gene Homer1 (D). E Bar graphs point out the significantly increased expression of C1q protein level in the CSF of MS patients showing Cognitive impairment (CI) compared with MS patients not showing CI (Student’s t test, p < 0.0001). All values are given as means ± SD.

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