Fig. 6: A ferroptosis-related gene signature characterizes ferroptosis-prone GC cell lines.
From: Salinomycin as a death switch: how gastric cancer cells choose their demise
Gene expression data of the four GC cell lines and gastric primary normal one (GES-1) were retrieved from public repositories. A In Venn diagram, differentially expressed genes (DEGs) numbers from comparisons of apoptosis- or ferroptosis-prone cell lines against normal stomach epithelial cell were reported (blue and pink, respectively). DEGs were filtered using p < 0.05. B DEGs, after excluding common genes between the two comparisons (white in Venn), were depicted in Volcano plots highlighting those matching with the three ferroptosis gene sets. C The heatmap highlights the 20 DEGs that defined the ferroptosis-related gene signature. DEGs were filtered for p < 0.05 and |log2FC| > 0.58 and reported as weighted Fold Change (logFC * -log10(p value)).
